# Leuprolide: track every shot, units to draw and what's still active

> Reconstitution calculator, as needed schedule, site rotation and half-life chart for Leuprolide. Track it in Peppy, private on your iPhone.

Source: https://peppytracker.com/compounds/leuprolide/
Last updated: 2026-09-02

GnRH agonist branded as Lupron and Eligard (depot); FDA-approved for prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. In the Peppy catalog, Leuprolide is reconstituted from a vial and drawn up in units on an insulin syringe, dosed in mg, typically as needed, with a listed half-life of about 3 hours.

## Frequently asked

### How many units is 1 mg of Leuprolide?

It depends on how the vial was mixed. Example: a 10 mg vial plus 2 mL of bacteriostatic water is 5 mg/mL, so 1 mg is 0.2 mL, or **20 units** on a U-100 insulin syringe. Change the water and the units change. Use the calculator above with your own vial, and verify with your prescriber.

### How long does Leuprolide stay in your system?

The Peppy catalog lists a half-life of about 3 hours for Leuprolide. After roughly five half-lives, about 15 hours, most of a single dose has cleared. That is an estimate from the half-life, not a measurement, and individual clearance varies.

### Can I track Leuprolide in Peppy?

Yes. Leuprolide is one of 123 compounds built into Peppy, with its form, unit and typical frequency prefilled. Add it as a protocol, set your schedule, and Peppy handles the countdown, the log and the reminders (Pro).

### Where should I inject Leuprolide?

Follow your prescriber's instructions. For subcutaneous shots the GLP-1 labels list the abdomen, thigh and upper arm and say to rotate. Peppy's body map has 13 sites, suggests the next one, and shows when each was last used. Read the [site rotation guide](https://peppytracker.com/guides/injection-site-rotation/).

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Peppy is a tracking tool, not medical advice. Dose calculations are mathematical conversions only. Always follow your prescriber's instructions and verify every draw-up yourself.

Peppy is a free iPhone app (Pro subscription optional). App Store: https://apps.apple.com/us/app/peptide-tracker-peppy/id6775005514