# Setmelanotide: track every shot and what's still active

> Daily schedule, site rotation and half-life chart for Setmelanotide. Track it in Peppy, private on your iPhone.

Source: https://peppytracker.com/compounds/setmelanotide/
Last updated: 2026-09-02

Melanocortin-4 receptor (MC4R) agonist branded as Imcivree; FDA-approved for obesity due to rare genetic deficiencies (POMC, PCSK1, LEPR). In the Peppy catalog, Setmelanotide is a pre-mixed injection, dosed in mg, typically daily, with a listed half-life of about 11 hours.

## Frequently asked

### How long does Setmelanotide stay in your system?

The Peppy catalog lists a half-life of about 11 hours for Setmelanotide. After roughly five half-lives, about 2.3 days, most of a single dose has cleared. That is an estimate from the half-life, not a measurement, and individual clearance varies.

### Can I track Setmelanotide in Peppy?

Yes. Setmelanotide is one of 123 compounds built into Peppy, with its form, unit and typical frequency prefilled. Add it as a protocol, set your schedule, and Peppy handles the countdown, the log and the reminders (Pro).

### Where should I inject Setmelanotide?

Follow your prescriber's instructions. For subcutaneous shots the GLP-1 labels list the abdomen, thigh and upper arm and say to rotate. Peppy's body map has 13 sites, suggests the next one, and shows when each was last used. Read the [site rotation guide](https://peppytracker.com/guides/injection-site-rotation/).

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Peppy is a tracking tool, not medical advice. Dose calculations are mathematical conversions only. Always follow your prescriber's instructions and verify every draw-up yourself.

Peppy is a free iPhone app (Pro subscription optional). App Store: https://apps.apple.com/us/app/peptide-tracker-peppy/id6775005514