Setmelanotide: track every shot and what's still active

Melanocortin-4 receptor (MC4R) agonist branded as Imcivree; FDA-approved for obesity due to rare genetic deficiencies (POMC, PCSK1, LEPR). In the Peppy catalog, Setmelanotide is a pre-mixed injection, dosed in mg, typically daily, with a listed half-life of about 11 hours.

CategoryFat loss & GLP-1
FormPre-mixed injection
Dose unitmg
Typical frequencyDaily
Half-life (catalog)~11 hours
Also known asImcivree, RM-493, BIM-22493

How long Setmelanotide stays active

Active in your system — Setmelanotide

estimate for daily doses, half-life 11 h
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Half-life ~11 hoursLeft after one daily interval 22%~5 half-lives to clear most of a dose 2.3 daysLevels out after about 4 doses

An estimate from the half-life, not a measurement. Individual clearance varies. Peppy shows this curve for each protocol under Active in your system.

Setmelanotide dose steps in the catalog

Setmelanotide — catalog dose ladderDose
Step 12 mg
Step 23 mg

Dose steps as listed in the Peppy catalog so the picker is fast — not a recommendation. Your prescriber sets your dose; Peppy tracks it.

How to track Setmelanotide in Peppy

  1. Open the Protocols tab, tap + and search for Setmelanotide (or Imcivree). Form, unit and typical frequency are prefilled.
  2. Enter your dose and pick a schedule. Titration step-ups and on/off cycles are available (Pro).
  3. Pick a colour and, for injections, a site rotation order. Peppy suggests the next site each time you log.
  4. On shot day, the Today tab counts down and one tap opens the Log shot sheet with the body map.
  5. Open the protocol to see Active in your system, the half-life curve for what you have logged (Pro).
  6. Log a daily check-in (side effects, feelings, weight) and see it lined up against every dose in Progress.

Track Setmelanotide in Peppy

Schedule, units, site rotation and reminders. Free on iPhone, no account.

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Frequently asked

How long does Setmelanotide stay in your system?

The Peppy catalog lists a half-life of about 11 hours for Setmelanotide. After roughly five half-lives, about 2.3 days, most of a single dose has cleared. That is an estimate from the half-life, not a measurement, and individual clearance varies.

Can I track Setmelanotide in Peppy?

Yes. Setmelanotide is one of 123 compounds built into Peppy, with its form, unit and typical frequency prefilled. Add it as a protocol, set your schedule, and Peppy handles the countdown, the log and the reminders (Pro).

Where should I inject Setmelanotide?

Follow your prescriber's instructions. For subcutaneous shots the GLP-1 labels list the abdomen, thigh and upper arm and say to rotate. Peppy's body map has 13 sites, suggests the next one, and shows when each was last used. Read the site rotation guide.

More in Fat loss & GLP-1

Not medical advice. Peppy is a tracking tool, not medical advice. Dose calculations are mathematical conversions only. Always follow your prescriber's instructions and verify every draw-up yourself.

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