Wegovy: a one-week half-life, five dose steps and your shot day
Wegovy is Novo Nordisk's once-weekly semaglutide pen approved for chronic weight management, titrated up to 2.4 mg to reduce appetite and food noise. The Peppy catalog lists it as a pen dosed in mg, weekly, with a half-life of about 165 hours. Peppy keeps the shot day, advances the five-step ladder and ties weight and side effects to each dose.
Looking for the medication page? See the GLP-1 tracker for iPhone: every shot, step-up and side effect in one place.
How long Wegovy stays active
Active in your system — Wegovy
estimate for weekly doses, half-life 165 hAn estimate from the half-life, not a measurement. Individual clearance varies. Peppy shows this curve for each protocol under Active in your system.
Wegovy dose steps in the catalog
| Wegovy — catalog dose ladder | Dose |
|---|---|
| Step 1 | 0.25 mg |
| Step 2 | 0.5 mg |
| Step 3 | 1 mg |
| Step 4 | 1.7 mg |
| Step 5 | 2.4 mg |
Dose steps as listed in the Peppy catalog so the picker is fast — not a recommendation. Your prescriber sets your dose; Peppy tracks it.
Tracking Wegovy: what matters
The Wegovy half life, about one week per the label, sets the rhythm: one shot a week, a level that climbs for roughly a month after each step, and a slow fade if you stop. Peppy's "active in your system" chart draws that from the catalog's 165-hour figure as an estimate. What you actually manage week to week is the ladder, the pens and the side effects.
Wegovy has five steps on the label, 0.25 through 2.4 mg, each held for 4 weeks. Dose step-ups (Pro) put that ladder on the calendar with a duration per rung; if your prescriber holds you longer at a step, you change one number. The card, the reminder and the Log shot sheet all show the dose for the current week, which stops the "was it 1 or 1.7 this week" moment. The titration tracker guide walks through it.
Wegovy pens are single-dose, so a box is four shots. Inventory (Pro) with one dose per pen counts them down and reminds you to refill about a week before the last one. And because appetite, nausea and food noise move with the steps, the daily check-in is where the value is: weight from Apple Health, side effects rated 1 to 5, and Progress (Pro insights) marks each step-up on the weight trend so you can see what changed when. See tracking food noise.
Schedule and cycles
The Peppy catalog lists Wegovy as weekly with a dose ladder of 0.25, 0.5, 1, 1.7 and 2.4 mg (catalog listing, not a recommendation). The label describes one shot a week on a consistent day, any time, with or without food, and says a missed shot is taken if the next dose is more than 48 hours away and skipped otherwise. Peppy computes missed and overdue from your schedule rather than storing them, so a late shot shows once on the day you took it. There is no cycling on the label; if your prescriber pauses you, use Pause on the protocol and resume when told.
How to do this in Peppy
- Open Protocols, tap +, search "Wegovy". Pen, mg, weekly and the half-life come from the catalog.
- Enter the current dose, weekday and time.
- Add the five rungs under Dose step-ups (Pro), 4 weeks each unless your prescriber says otherwise.
- Enter pens in Inventory (Pro) with one dose per pen.
- On shot day, tap the countdown on Today, choose the suggested site on the body map and log. Turn on Settings > Reminders (Pro).
- Do the check-in daily, especially the week after a step-up, and review Progress before appointments.
The Wegovy tracker page covers the weekly routine end to end.
Track it in Peppy
123 compounds built in, the units math done for you, body-map site rotation and reminders — private on your iPhone.
Free · iPhone · no accountFrequently asked
What is the Wegovy half life?
The Wegovy label reports an elimination half-life of approximately 1 week for semaglutide. The Peppy catalog lists 165 hours and uses it for the "active in your system" estimate, which is why the chart shows the level climbing over the first weeks at each dose.
What if I miss a Wegovy shot?
Wegovy's dosing information says to take the missed shot as soon as possible if the next scheduled dose is more than 2 days (48 hours) away, and to skip it if the next dose is less than 2 days away. Peppy shows the missed shot and the next due date; the decision is your prescriber's. See the missed dose guide.
How does the Wegovy dose schedule work?
The label escalates every 4 weeks: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, then the 2.4 mg maintenance dose. Peppy's dose step-ups (Pro) model that ladder with a duration per rung and advance automatically. Your prescriber may slow it down; edit the durations to match.
How often is Wegovy taken?
The Peppy catalog lists Wegovy as weekly, matching the once-weekly label. Set the weekday in Peppy and the countdown, reminder (Pro) and widget (Pro) follow it.
Where do you inject Wegovy?
The label lists abdomen, thigh or upper arm. Peppy's body map records each site and suggests the next one. See the rotation guide.
How long does Wegovy stay in your system?
The Peppy catalog lists a half-life of about 6.9 days for Wegovy. After roughly five half-lives, about 4.9 weeks, most of a single dose has cleared. That is an estimate from the half-life, not a measurement, and individual clearance varies.
Can I track Wegovy in Peppy?
Yes. Wegovy is one of 123 compounds built into Peppy, with its form, unit and typical frequency prefilled. Add it as a protocol, set your schedule, and Peppy handles the countdown, the log and the reminders (Pro).
Where should I inject Wegovy?
Follow your prescriber's instructions. For subcutaneous shots the GLP-1 labels list the abdomen, thigh and upper arm and say to rotate. Peppy's body map has 13 sites, suggests the next one, and shows when each was last used. Read the site rotation guide.
More in Fat loss & GLP-1
Sources
Not medical advice. Peppy is a tracking tool, not medical advice. Dose calculations are mathematical conversions only. Always follow your prescriber's instructions and verify every draw-up yourself.