Ozempic: a one-week half-life, your shot day and the dose step-ups
Ozempic is Novo Nordisk's once-weekly semaglutide pen approved for type 2 diabetes, a GLP-1 receptor agonist that slows gastric emptying and curbs appetite. The Peppy catalog lists it as a pen dosed in mg, weekly, with a half-life of about 165 hours. Peppy tracks the shot day, advances the dose step-ups and charts what is still active.
Looking for the medication page? See the GLP-1 tracker for iPhone: every shot, step-up and side effect in one place.
How long Ozempic stays active
Active in your system — Ozempic
estimate for weekly doses, half-life 165 hAn estimate from the half-life, not a measurement. Individual clearance varies. Peppy shows this curve for each protocol under Active in your system.
Ozempic dose steps in the catalog
| Ozempic — catalog dose ladder | Dose |
|---|---|
| Step 1 | 0.25 mg |
| Step 2 | 0.5 mg |
| Step 3 | 1 mg |
| Step 4 | 2 mg |
Dose steps as listed in the Peppy catalog so the picker is fast — not a recommendation. Your prescriber sets your dose; Peppy tracks it.
Tracking Ozempic: what matters
The Ozempic half life is about one week, per the label, and that single number explains most of what you need to track. It is why the shot is weekly, why the label gives a 5-day window for a missed dose, and why the level in your body builds over the first month at each step. Peppy's "active in your system" chart draws that build-up from the catalog's 165-hour figure; it is an estimate from the half-life, not a measurement, and the semaglutide guide explains how to read it.
Because it is a pen, there is no units math. The things that matter are the day, the dose and the pen count. Ozempic pens deliver several doses each, so an inventory (Pro) entry of pens times doses per pen gives you "≈ 6 doses left, runs out around Oct 3" and a refill reminder before you are stuck.
The dose changes over time. The label's ladder starts at 0.25 mg for 4 weeks, then 0.5 mg, with 1 mg and 2 mg as later steps. Dose step-ups (Pro) put your prescriber's version of that ladder on the calendar, so the Today card, the reminder and the log sheet all show the right mg on the right week. The titration tracker guide covers the setup. Side effects tend to move with the steps, and the daily check-in ties nausea, constipation and food noise to the dose you were on.
Schedule and cycles
The Peppy catalog lists Ozempic as weekly with a dose ladder of 0.25, 0.5, 1 and 2 mg (catalog listing, not a recommendation). The label describes one shot a week, on the same day, any time of day, with or without food. It allows the weekday to change as long as two doses are at least 48 hours apart. Missed and overdue shots are computed by Peppy from the schedule, so a shot logged two days late shows once, on the day you took it. There is no cycling pattern on the label; if your prescriber pauses you, use Pause on the protocol so the calendar does not fill with missed dots.
How to do this in Peppy
- Open Protocols, tap +, search "Ozempic". The catalog sets pen, mg, weekly and the half-life.
- Enter the current dose and pick the weekday and time.
- Add rungs under Dose step-ups (Pro) with a duration for each, as your prescriber laid them out.
- Enter pens and doses per pen in Inventory (Pro) for the refill reminder.
- On shot day, tap the countdown on Today, pick the suggested site on the body map and log. Turn on Settings > Reminders (Pro) with a missed nudge.
- Log weight and side effects in the daily check-in; Progress (Pro insights) marks each step-up on your weight trend.
The Ozempic tracker page has the full weekly routine.
Track it in Peppy
123 compounds built in, the units math done for you, body-map site rotation and reminders — private on your iPhone.
Free · iPhone · no accountFrequently asked
What is the Ozempic half life?
The Ozempic label states an elimination half-life of approximately 1 week and says semaglutide stays in the circulation for about 5 weeks after the last dose. The Peppy catalog lists 165 hours, and the "active in your system" chart uses that number as an estimate.
What if I miss my Ozempic shot?
The Ozempic label says to take a missed dose as soon as possible within 5 days after the missed dose, and otherwise skip it and take the next dose on the regular day. Peppy shows a missed shot on the Today tab and calendar so you know where you are; what to do about it is your prescriber's call. See the missed dose guide.
Can I change my Ozempic shot day?
The label says the weekly day can be changed if the time between two doses is at least 2 days (48 hours). In Peppy, edit the protocol's weekday; upcoming shots move and past logs stay where they were.
How does the Ozempic dose step-up work?
The label starts at 0.25 mg weekly for 4 weeks, then 0.5 mg, with later increases to 1 mg and 2 mg if needed, each after at least 4 weeks. Peppy's dose step-ups (Pro) put that ladder on the calendar and advance the dose on the card and reminder. Your prescriber sets the actual steps.
Where do you inject Ozempic?
The label lists the abdomen, thigh or upper arm. Peppy's body map suggests the next site and shows when each was last used. See the rotation guide.
How long does Ozempic stay in your system?
The Peppy catalog lists a half-life of about 6.9 days for Ozempic. After roughly five half-lives, about 4.9 weeks, most of a single dose has cleared. That is an estimate from the half-life, not a measurement, and individual clearance varies.
Can I track Ozempic in Peppy?
Yes. Ozempic is one of 123 compounds built into Peppy, with its form, unit and typical frequency prefilled. Add it as a protocol, set your schedule, and Peppy handles the countdown, the log and the reminders (Pro).
Where should I inject Ozempic?
Follow your prescriber's instructions. For subcutaneous shots the GLP-1 labels list the abdomen, thigh and upper arm and say to rotate. Peppy's body map has 13 sites, suggests the next one, and shows when each was last used. Read the site rotation guide.
More in Fat loss & GLP-1
Not medical advice. Peppy is a tracking tool, not medical advice. Dose calculations are mathematical conversions only. Always follow your prescriber's instructions and verify every draw-up yourself.