MOTS-c: units to draw, an every-other-day schedule and vial life

MOTS-c is a mitochondrial-derived 16-amino-acid peptide that activates AMPK signalling, researched for metabolic health, insulin sensitivity and exercise-mimetic longevity effects. The Peppy catalog lists it as a reconstituted vial dosed in mg, typically every other day, with no half-life on file. Peppy converts vial and water into units and keeps the alternating-day schedule.

CategoryLongevity
FormVial (reconstitute)
Dose unitmg
Typical frequencyEvery other day
Also known asMitochondrial Open Reading Frame of the 12S rRNA-c

MOTS-c reconstitution calculator

MOTS-c reconstitution calculator

Free in the app
100units
to draw on a U-100 insulin syringe · 1 mL
0102030405060708090100
Concentration5 mg/mL
Per unit50 mcg
Doses per vial2
Mathematical conversion only. Always verify with your prescriber. MOTS-c tracker page → Save it in Peppy

MOTS-c dose steps in the catalog

MOTS-c — catalog dose ladderDose
Step 15 mg
Step 210 mg

Dose steps as listed in the Peppy catalog so the picker is fast — not a recommendation. Your prescriber sets your dose; Peppy tracks it.

Tracking MOTS-c: what matters

MOTS-c is dosed in whole milligrams, and the doses are large relative to the vial, which makes a MOTS-c reconstitution calculator mostly about the syringe limit. A 10 mg vial with 1 mL of water is 10 mg per mL: a 5 mg shot is 50 units and a 10 mg shot is the entire millilitre. Add 2 mL and a 10 mg shot no longer fits a 1 mL syringe at all; Peppy warns when that happens so you can pick a water volume that works. The mix is stored on the protocol and the units appear on the card, the reminder and the Log shot sheet. See units to draw.

The vial is the other thing to count. At 5 mg every other day, a 10 mg vial is two shots and lasts four days. Inventory (Pro) turns vials times doses per vial into a run-out date and a running-low alert, which matters when the reorder lead time is longer than the vial. The inventory guide covers partial vials.

There is no half-life on file, so Peppy does not draw an "active in your system" curve for MOTS-c. What it does show is the schedule and your check-ins side by side; energy is a tracked feeling, and Progress (Pro insights) lines it up with shot days.

Schedule and cycles

The Peppy catalog lists MOTS-c as every other day, with a dose ladder of 5 and 10 mg (catalog listing, not a recommendation). Alternating days are the pattern that trips up a simple daily reminder, and it is the one Peppy's every-other-day schedule was built for: the calendar shows the next shot two days out, and the Today countdown reads "Due in 1d 6h" on the off day. People also log three fixed weekdays or blocks such as 4 weeks on and 4 off; a custom weekday schedule handles the first and cycles (Pro) the second, auto-skipping off days so they never appear as missed. The cycle tracker guide shows both. Which pattern fits you is your prescriber's call.

The Calendar tab for August 2026 with taken, missed, upcoming and skipped dots on each day
Taken, missed, upcoming, skipped. Never a duplicate.

How to do this in Peppy

  1. Open Protocols, tap +, search "MOTS-c". The catalog sets vial, mg and every other day.
  2. Enter the mg dose. In the inline Calculator, type vial mg and water mL; if Peppy warns about the 1 mL limit, lower the water volume.
  3. Set the time and confirm the every-other-day schedule, or switch to fixed weekdays. Add Cycles (Pro) for on/off blocks.
  4. Enter vials in Inventory (Pro); with two shots per vial, the running-low alert matters.
  5. Log from Today, tapping the suggested site on the body map. Log a forgotten shot from the Calendar with the real time.
  6. Do the daily check-in so energy and sleep are recorded on both shot and off days.

Many people track MOTS-c alongside NAD+; the stack tracker guide covers running both.

Track it in Peppy

123 compounds built in, the units math done for you, body-map site rotation and reminders — private on your iPhone.

Download on the App StoreFree · iPhone · no account

Frequently asked

How many units is 5 mg of MOTS-c?

Example: a 10 mg vial mixed with 1 mL of bacteriostatic water is 10 mg per mL, so 5 mg is 0.5 mL, or 50 units on a U-100 syringe; 10 mg is the whole millilitre. With 2 mL of water, 5 mg is 100 units. Enter your vial and water in Peppy's calculator and verify with your prescriber.

How often is MOTS-c typically scheduled?

The Peppy catalog lists MOTS-c as every other day. Some people log it three times a week or in multi-week blocks. Peppy's every-other-day schedule, custom weekday schedules and cycles (Pro) cover all three. Your prescriber decides the pattern.

What is MOTS-c's half-life?

The Peppy catalog does not list one, so the "active in your system" chart is not shown for MOTS-c. Published human pharmacokinetic data are limited, and Peppy does not estimate a number it cannot source.

Where do you inject MOTS-c?

Most people log subcutaneous sites: abdomen, thighs, upper arms. Peppy's body map suggests the next site and shows when each was last used. See the rotation guide.

Can I track MOTS-c in Peppy?

Yes. MOTS-c is one of 123 compounds built into Peppy, with its form, unit and typical frequency prefilled. Add it as a protocol, set your schedule, and Peppy handles the countdown, the log and the reminders (Pro).

Where should I inject MOTS-c?

Follow your prescriber's instructions. For subcutaneous shots the GLP-1 labels list the abdomen, thigh and upper arm and say to rotate. Peppy's body map has 13 sites, suggests the next one, and shows when each was last used. Read the site rotation guide.

More in Longevity

Not medical advice. Peppy is a tracking tool, not medical advice. Dose calculations are mathematical conversions only. Always follow your prescriber's instructions and verify every draw-up yourself.

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